Article: A functional null mutation of SCN1B in a patient with Dravet syndrome.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Patino GA; Claes LR; Lopez-Santiago LF; Slat EA; Dondeti RS; Chen C; O'Malley HA; Gray CB; Miyazaki H; Nukina N; Oyama F; De Jonghe P; Isom LL J. Neurosci., 2009
HEKrNav1.1 | HEKrNav1.1 + β1WT | HEKrNav1.1 + p.R125C | |
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Voltage dependence of activation | |||
V1/2 (mV) | −18.27 ± 1.53 | −19.09 ± 1.79 | −18.49 ± 0.92 |
k | −7.54 ± 0.35 | −6.52 ± 0.54 | −6.87 ± 0.26 |
n | 12 | 9 | 11 |
Voltage dependence of inactivation | |||
V1/2 (mV) | −55.52 ± 1.32 | −54.18 ± 0.77 | −54.30 ± 1.47 |
k | 4.73 ± 0.22 | 4.59 ± 0.13 | 4.79 ± 0.21 |
C | 0.04 ± 0.01 | 0.05 ± 0.01 | 0.60 ± 0.01 |
n | 11 | 9 | 11 |
Kinetics of inactivation, one exponential | |||
τslow (ms) | 0.63 ± 0.06 | 0.42 ± 0.03* | 0.59 ± 0.03 |
n | 11 | 8 | 10 |
Kinetics of inactivation, two exponentials | |||
τslow (ms) | 25.07 ± 12.99 | 6.95 ± 3.18 | 16.10 ± 8.68 |
Amplitudeslow (%) | 7.72 ± 1.65 | 4.43 ± 2.35 | 5.20 ± 4.84 |
τfast (ms) | 0.48 ± 0.05 | 0.34 ± 0.01 | 0.46 ± 0.02 |
Amplitudefast (%) | 92.27 ± 1.65 | 95.56 ± 2.35 | 94.79 ± 1.45 |
n | 11 | 8 | 10 |
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Data are mean ± SEM.
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↵*p < 0.05 compared with Nav1.1.
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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